There's a handy KDE System Settings module for configuring Wacom tablets - calibration, screen areas, you name it. I was rather keen to have it handle my old Graphire4 on a multi screen setup on my work desktop (Ubuntu 16.05).
Sadly, the wacomtablet package (https://github.com/KDE/wacomtablet) seems to have been dropped from the repos between 14.04 and 19.04 due to ongoing bugfixes in dependencies.
They do offer instructions for manual compiling - with dire warnings that there'd there be no easy uninstall. 'make uninstall' worked nicely, though.
However, I kept running into missing headers etc., until I found the one version that worked, 2.9.82.
Command line log:
wget https://github.com/KDE/wacomtablet/archive/v2.9.82.zip
unzip v2.9.82.zip
cd wacomtablet-2.9.82
mkdir build
cd build
cmake ../ -DCMAKE_INSTALL_PREFIX=/usr -DCMAKE_BUILD_TYPE=Release -DKDE_INSTALL_USE_QT_SYS_PATHS=ON
make
sudo make install
Et voilĂ !